2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12781S
    Desbutyl Lumefantrine-d9
    Desbutyl Lumefantrine-d9 is the deuterium labeled euterium labeled, which is a metabolite of Lumefantrine.
    Desbutyl Lumefantrine-d<sub>9</sub>
  • HY-113364
    5α-Tetrahydrocorticosterone
    5α-Tetrahydrocorticosterone (5α-HB), an endogenous steroid, is a glucocorticoid receptor (GR) agonist and a metabolite of Corticosterone (HY-B1618). 5α-Tetrahydrocorticosterone is an effective topical anti-inflammatory agent in vivo. 5α-Tetrahydrocorticosterone reduces metabolites that bind to GR-Corticosterone and its 5α-reduced metabolites in rat hepatocytes, with a Kd of 268 nM. 5α-Tetrahydrocorticosterone can be used for research on inflammatory skin diseases.
    5α-Tetrahydrocorticosterone
  • HY-118116
    bicyclo-PGE2
    bicyclo-PGE2 (bicyclo-PGEM) is a stable decomposition product of PGE2 and 13, 14-dihydro-15-ketone PGE2.
    bicyclo-PGE2
  • HY-Z2106S
    Vonoprazan impurity 11-d5 fumarate
    Vonoprazan impurity 11-d5 (fumarate) is deuterium labeled 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylmethanamine (Vonoprazan Impurity).
    Vonoprazan impurity 11-d<sub>5</sub> fumarate
  • HY-113468AS1
    3-O-Methyldopa-d3 hydrate
    3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease.
    3-O-Methyldopa-d<sub>3</sub> hydrate
  • HY-121345
    Homobaldrinal
    Homobaldrinal is a decomposition product of Valepotriate (HY-N0718). Homobaldrinal exhibits genotoxic activity in the Salmonella/microsome test.
    Homobaldrinal
  • HY-169463
    11-Hydroxy cannabinol
    11-Hydroxy cannabinol (Compound 5b) is an active metabolite of Cannabinol.
    11-Hydroxy cannabinol
  • HY-15550R
    4'-Hydroxy diclofenac (Standard)
    4'-Hydroxy diclofenac (Standard) is the analytical standard of 4'-Hydroxy diclofenac. This product is intended for research and analytical applications. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties.
    4'-Hydroxy diclofenac (Standard)
  • HY-133668R
    Monoethyl phthalate (Standard)
    Sulfamonomethoxine (sodium) (Standard) is the analytical standard of Sulfamonomethoxine (sodium). This product is intended for research and analytical applications. Sulfamonomethoxine sodium is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
    Monoethyl phthalate (Standard)
  • HY-113104
    Androsterone glucuronide
    Androsterone glucuronide (ADT-G) is one of the main metabolites of oral testosterone in humans and can be found in urine. The level of Androsterone glucuronide can reflect the absorption and hepatic metabolism of testosterone.
    Androsterone glucuronide
  • HY-135374
    (3R,5S)-Atorvastatin sodium
    (3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    (3R,5S)-Atorvastatin sodium
  • HY-114976
    S-Allylmercapturic acid
    S-Allylmercapturic acid is a biomarker of food intake (BFIs) for garlic consumption.
    S-Allylmercapturic acid
  • HY-145461
    Hydroxy lenalidomide
    Hydroxy lenalidomide (5-Hydroxy lenalidomide) is a metabolite of lenalidomide that is present as a minor component in plasma and excreta, accounting for less than 5% of the total radioactivity, following oral administration of lenalidomide in healthy male subjects.
    Hydroxy lenalidomide
  • HY-W709755
    Mono(5-carboxy-2-ethylpentyl) phthalate-d9
    Mono(5-carboxy-2-ethylpentyl) phthalate-d9 (MECPP-d9) is the deuterium labeled Mono(5-carboxy-2-ethylpentyl) phthalate (HY-133675). Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(5-carboxy-2-ethylpentyl) phthalate-d<sub>9</sub>
  • HY-W653885
    rac 3,4-Dihydroxymandelic Acid-d3
    rac 3,4-Dihydroxymandelic Acid-d3 is deuterium labeled 3,4-Dihydroxymandelic acid. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine.
    rac 3,4-Dihydroxymandelic Acid-</sub>d<sub>3</sub>
  • HY-N10403R
    4-Hydroxyestradiol (Standard)
    ABZ-amine (Standard) is the analytical standard of ABZ-amine. This product is intended for research and analytical applications. ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations.
    4-Hydroxyestradiol (Standard)
  • HY-126852
    4-Hydroxy Atorvastatin lactone
    4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    4-Hydroxy Atorvastatin lactone
  • HY-W100784
    2,6-Dimethylphenylthiourea
    		99.81%
    2,6-Dimethylphenylthiourea is a Xylazine metabolite. Xylazine is the first and most widely used α2-agonist.
    2,6-Dimethylphenylthiourea
  • HY-125446S
    2-Hydroxymethyl olanzapine-d3
    2-Hydroxymethyl olanzapine-d3 (LY-290411-d3) is a deuterium labeled 2-Hydroxymethyl olanzapine. 2-Hydroxymethyl olanzapine is a metabolite of Olanzapine..
    2-Hydroxymethyl olanzapine-d<sub>3</sub>
  • HY-131964R
    Imidacloprid-urea (Standard)
    Sodium ethylparaben (Standard) is the analytical standard of Sodium ethylparaben. This product is intended for research and analytical applications. Sodium ethylparaben (Sodium ethyl 4-hydroxybenzoate) acts as a water soluble antiseptic usually employed as safe for cosmetics.
    Imidacloprid-urea (Standard)
Cat. No. Product Name / Synonyms Application Reactivity