2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135389S1
    Desmethyl Levofloxacin-d8
    Desmethyl Levofloxacin-d8 is deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
    Desmethyl Levofloxacin-d<sub>8</sub>
  • HY-142217S
    Quetiapine dimer impurity-d8
    Quetiapine dimer impurity-d8 is the deuterium labeled Quetiapine dimer impurity.
    Quetiapine dimer impurity-d<sub>8</sub>
  • HY-108263A
    (S)-3-Hydroxy Midostaurin
    (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML).
    (S)-3-Hydroxy Midostaurin
  • HY-N7080R
    Dihydroferulic acid (Standard)
    Dihydroferulic acid (Standard) is the analytical standard of Dihydroferulic acid. This product is intended for research and analytical applications. Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid[1][2].
    Dihydroferulic acid (Standard)
  • HY-13256AS1
    Desmethyl Erlotinib-d4-1
    Desmethyl Erlotinib-d4-1 (OSI-420-d4-1 (free base); CP-373420-d4-1) is deuterium-labeled Desmethyl Erlotinib (HY-13256A).
    Desmethyl Erlotinib-d4-1
  • HY-W009538S1
    5'-Deoxy-5-fluorocytidine-13C5
    5'-Deoxy-5-fluorocytidine-13C5 is the 13C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
    5'-Deoxy-5-fluorocytidine-<sup>13</sup>C<sub>5</sub>
  • HY-138813R
    N-Desethyl Sunitinib hydrochloride (Standard)
    Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).
    N-Desethyl Sunitinib hydrochloride (Standard)
  • HY-N4173R
    8-Oxoepiberberine (Standard)
    p-Dimethylaminobenzaldehyde (Standard) is the analytical standard of p-Dimethylaminobenzaldehyde. This product is intended for research and analytical applications. p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles.
    8-Oxoepiberberine (Standard)
  • HY-N0384S5
    Homovanillic acid-13C,d3
    Homovanillic acid-13C,d3 is 13C and deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic acid-<sup>13</sup>C,d<sub>3</sub>
  • HY-135910S
    3,4-Dehydro Cilostazol-d11
    3,4-Dehydro Cilostazol-d11 is deuterated labeled 3,4-Dehydro Cilostazol (HY-135910). 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study.
    3,4-Dehydro Cilostazol-d<sub>11</sub>
  • HY-127118A
    Pteropterin monohydrate
    Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity.
    Pteropterin monohydrate
  • HY-137386
    2-Oxo-3-hydroxy-LSD
    2-Oxo-3-hydroxy-LSD is a metabolite of Lysergic acid diethylamide.
    2-Oxo-3-hydroxy-LSD
  • HY-12771S2
    O-Desmethyl Mebeverine acid-d6
    O-Desmethyl Mebeverine acid-d6 is deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl Mebeverine acid-d<sub>6</sub>
  • HY-101671R
    S-methyl-KE-298 (Standard)
    S-methyl-KE-298 (Standard) is the analytical standard of S-methyl-KE-298. This product is intended for research and analytical applications. S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298 (Standard)
  • HY-136611S
    ω-Hydroxy-DEET-d10
    ω-Hydroxy-DEET-d10 is the deuterium labeled ω-Hydroxy-DEET (HY-136611). ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes.
    ω-Hydroxy-DEET-d<sub>10</sub>
  • HY-136381
    N-Nitrosoglyphosate sodium
    N-Nitrosoglyphosate sodium is the nitrosamine degradation product and synthetic impurity of glyphosate herbicide.
    N-Nitrosoglyphosate sodium
  • HY-135586R
    Raloxifene N-Oxide (Standard)
    Raloxifene N-Oxide (Standard) is the analytical standard of Raloxifene N-Oxide. This product is intended for research and analytical applications. Raloxifene N-Oxide is a Raloxifene oxidative degradation product.
    Raloxifene N-Oxide (Standard)
  • HY-118620R
    Nortriptyline (Standard)
    Nortriptyline (Standard) is the analytical standard of Nortriptyline. This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects. N
    Nortriptyline (Standard)
  • HY-G0002S
    Lurasidone Metabolite 14326-d8
    Lurasidone Metabolite 14326-d8 is the deuterium labeled Lurasidone Metabolite 14326, which is a metabolite of Lurasidone.
    Lurasidone Metabolite 14326-d<sub>8</sub>
  • HY-Y1117R
    Melamine (Standard)
    Melamine (Standard) is the analytical standard of Melamine. This product is intended for research and analytical applications. Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials.
    Melamine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity